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Males and females exhibit distinct anatomic and functional characteristics of the heart, predisposing them to specific disease states.
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This suggests that their regulatory mechanism or mechanisms temper excessive immune responses in SJS/TEN with SOC. The differential regulation of innate immunity-related genes by miRNAs, e.g. let-7a-5p, hsa-let-7e-5p, miR-146a-5p, and miR-27b-3p, which up-regulate TLR3, RIG-I, and MDA5, and by miR-130a-3p and let-7d-3p, which down-regulate these genes, illustrates the complexity of immune responses in SJS/TEN with SOC (Fig. 4).Mirna Brothel
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